The Tal lab studies whether host-associated microbiota modify the developmental toxicity of environmental chemicals. The group also works to resolve how early life stage thyroid hormone disruption impacts brain development and function in zebrafish.
El-Masri H, Kleinstreuer N, Hines R, Adams L, Tal T, Isaacs K, Wetmore B, and Tan Y. Integration of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models with Adverse Outcome Pathways (AOPs) and Environmental Exposure Models to Screen for Environmental Hazards. Tox Sci 2016.
Tal TL, McCollum CW, Harris P, Olin J, Kleinstreuer N, Wood CE, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TK, Padilla S, and Hemmer MK. Immediate and long-term consequences of vascular toxicity during development using a quantitative vascular disruption assay in zebrafish. Reproductive Toxicology. DOI: 10.1016/j.reprotox.2014.05.014
Franzosa JA, Bugel SM, Tal TL, La Du JK, Tilton SC, Waters KM, and Tanguay RL. Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects. FASEB J,2013.
Schug TT, Abagyan R, Blumberg B, Collins TJ, Crews D, DeFur PL, Dickerson SM, Edwards TM, Gore AC, Guillette LJ, Hayes T, Heindel J, Moores A, Patisaul HB, Tal TL, Thayer KA, Vandenberg LN, Warner JC, Watson CS, vom Saal FS, Zoeller RT, O’Brien KP and Myers JP. Designing endocrine disruption out of the next generation of chemicals. Green Chemistry, 2013,15, 181-198
Tilton SC, Tal TL, Scroggins SM, Gibson TD, Franzosa JA, Peterson EA, Tanguay RL, Waters KM. Bioinformatics Resource Manager v2.3: An integrated software environment for systems biology with microRNA and cross-species analysis tools. BMC Bioinformatics. 2012; 13:311.
Tal TL, Franzosa JA, Tamara, Tilton S, Philbrick K, Iwaniec U, Turner R, Waters K, and Tanguay RL. microRNAs control neurobehavioral development and function in zebrafish. FASEB J. 2012; 26(4):1452-61.
Tal TL and Tanguay RL. Non-coding RNAs - novel targets in neurotoxicity. Neurotoxicology. 2012; 33(3):530-44.
Tal TL, Franzosa JA, Tanguay RL. Molecular Signaling Networks That Choreograph Epimorphic Fin Regeneration in Zebrafish - A Mini-Review. Gerontology. 2010; 56(2):231-40.
Samet JM and Tal TL. Toxicological disruption of signaling homeostasis: tyrosine phosphatases as targets. Annu Rev Pharmacol Toxicol.2010;50:215-35.
Tal TL, Simmons S, Silbajoris R, Dailey L, Cho SH, Ramabhadran R, Linak W, Reed W, Bromberg PA, Samet JM. Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles. Toxicol Appl Pharmacol. [Epub ahead of print] PubMed PMID: 19914270.
Silbajoris R, Huang JM, Cheng WY, Dailey L, Tal TL, Jaspers I, Ghio AJ, Bromberg PA, and Samet JM. Nanodiamond particles induce IL-8 expression through a transcript stabilization mechanism in human airway epithelial cells. Nanotoxicol. 2009; 3, 152-160.
Tal TL, Bromberg PA, Kim Y, Samet JM. Epidermal growth factor receptor activation by diesel particles is mediated by tyrosine phosphatase inhibition. Toxicol Appl Pharmacol. 2008 Dec 15;233(3):382-8. Epub 2008 Sep 26. PubMed PMID: 18926838.
Kim YM, Cao D, Reed W, Wu W, Jaspers I, Tal TL, Bromberg PA, Samet JM. Zn2+-induced NF-kappaB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation. Cell Signal. 2007 Mar;19(3):538-46. Epub 2006 Aug 22. PubMed PMID: 17008051.
Cao D, Tal TL, Graves LM, Gilmour I, Linak W, Reed W, Bromberg PA, Samet JM. Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. Epub 2006 Oct 6. PubMed PMID: 17028263.
Tal TL, Graves LM, Silbajoris R, Bromberg PA, Wu W, Samet JM. Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+. Toxicol Appl Pharmacol. 2006 Jul 1;214(1):16-23. Epub 2006 Jan 10. PubMed PMID: 16410015.
|First place, Reproductive and Developmental Specialty Section Postdoctoral Poster Award||Society of Toxicology||2015|
|First place, Drug Discovery Toxicology Specialty Section Postdoctoral Poster Award||Society of Toxicology||2015|
|U.S. EPA Pathfinder Innovation Project Stage Two Award||U.S. Environmental Protection Agency||RTP, NC||2015|
|U.S. EPA Pathfinder Innovation Project Stage One Award||U.S. Environmental Protection Agency||RTP, NC||2014|
|Future Tox II Research Award||2014|
|NLTO Annual Oral Presentation Competition - First Place||U.S. Environmental Protection Agency||RTP, NC||2012|
|Gabriel L. Plaa Education Award, Mechanisms Specialty Section - Runner-up||Society of Toxicology||Washington, D.C.||2011|
|Environmental Health News Science Communication Fellow||Environmental Health News||USA||2011|
|Trainee Poster Award - Second Place||Pacific Northwest Association of Toxicologists Regional Conference||Corvallis, OR||2010|
|Postdoctoral Research Award - First Place||International Neurotoxicology Conference||Portland, OR||2010|
|Molecular Biology Specialty Section Postdoctoral Research Award - First Place||Society of Toxicology||Salt Lake City, UT||2010|
|Neurotoxicology Specialty Section Postdoctoral Poster Award - Second Place||Society of Toxicology||Salt Lake City, UT||2010|
|NIEHS Postdoctoral Fellow||Department of Environmental and Molecular Toxicology||Oregon State University||2008-2010|
|Inhalation Specialty Section Graduate Student Award||Society of Toxicology||Seattle, WA||2008|
|Graduate Student Travel Award||Society of Toxicology||Seattle, WA||2008|
|Graduate Education Advancement Board Impact Award||University of North Carolina at Chapel Hill||Chapel Hill, NC||2007|
|NIH National Graduate Student Research Festival Award||National Institute of Health||Chapel Hill, NC||2007|
|North Carolina Graduate Student Award||Society of Toxicology||Research Triangle Park, NC||2006|
|Metals Specialty Section Student Award||Society of Toxicology||San Diego, CA||2006|
|North Carolina Graduate Student Award||Society of Toxicology||Chapel Hill, NC||2005|
|Florida Bright Future Scholarship||State of Florida||Florida||1998-2003|
|Honors College||University of Central Florida||Gainesville, FL||1998-2003|
Tal TL, High levels of PCBs tied to defective sperm in infertile men. Environmental Health News, February 28, 2012.
Tal TL, Genetically speaking, captivity is fishy business. Environmental Health News, February 3, 2012.
Tal TL, Article overlooks chemical’s role in determining fish sex. Environmental Health News, January 19, 2012.
Tal TL and Hessler W, Toxic legacy: Fish pass flame retardants, impaired health to offspring. Environmental Health News, January 11, 2012.
Tal TL and Hessler W, Moms and POPs: birth defects linked to banned, current pollutants. Environmental Health News, October 13, 2011.
Tal TL, New screen IDs vascular system’s chemical enemies. Environmental Health News, September 21, 2011.
Tal TL, Chemicals’ role in frog deaths missed. Environmental Health News, August 8, 2011.
Tal TL, Article on fungicide toxicity unnecessarily casts doubt on findings. Environmental Health News, April 29, 2011.
Tal TL, Headline misrepresents food dye panel’s findings. Environmental Health News, April 8, 2011.
The information contained here does not necessarily reflect the views of the Environmental Protection Agency.